Drug interactions
Dimenhydrinate + Haloperidol
Severity: Moderate
Dimenhydrinate and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate, which releases diphenhydramine, is a sedating antihistamine with anticholinergic effects. Together with haloperidol it increases drowsiness and anticholinergic effects.
What this interaction means in plain words
Dimenhydrinate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Counsel about sedation and avoid driving. Reduce the dose or choose an alternative antiemetic if confusion or excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Haloperidol?
MediHelp rates the interaction as moderate. Dimenhydrinate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate, which releases diphenhydramine, is a sedating antihistamine with anticholinergic effects. Together with haloperidol it increases drowsiness and anticholinergic effects.
How serious is the interaction between Dimenhydrinate and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about sedation and avoid driving. Reduce the dose or choose an alternative antiemetic if confusion or excess sedation occurs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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