Drug interactions
Dimenhydrinate + Hydroxyzine
Severity: Moderate
Dimenhydrinate and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating antihistamines with anticholinergic properties. Combined use increases drowsiness, impaired alertness and anticholinergic effects, and hydroxyzine adds a QT prolongation risk.
What this interaction means in plain words
Dimenhydrinate and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Hydroxyzine belongs to Respiratory.
Why it happens
Additive central H1-receptor antagonism and muscarinic blockade.
What to do
Avoid combining and use a single agent at the lowest effective dose. Monitor older patients for confusion, falls and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Dimenhydrinate with Hydroxyzine?
MediHelp rates the interaction as moderate. Dimenhydrinate and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating antihistamines with anticholinergic properties. Combined use increases drowsiness, impaired alertness and anticholinergic effects, and hydroxyzine adds a QT prolongation risk.
How serious is the interaction between Dimenhydrinate and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining and use a single agent at the lowest effective dose. Monitor older patients for confusion, falls and urinary retention.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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