Drug interactions
Dimenhydrinate + Iloperidone
Severity: Moderate
Dimenhydrinate and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, and dimenhydrinate also has antimuscarinic effects that overlap with iloperidone's. Together they may cause marked drowsiness, dizziness and orthostatic effects.
What this interaction means in plain words
Dimenhydrinate and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression through histamine H1 and other receptor antagonism, plus additive anticholinergic effects.
What to do
Monitor for sedation, orthostatic hypotension and anticholinergic effects, especially in older adults. Reduce the dose or avoid dimenhydrinate if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dimenhydrinate with Iloperidone?
MediHelp rates the interaction as moderate. Dimenhydrinate and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, and dimenhydrinate also has antimuscarinic effects that overlap with iloperidone's. Together they may cause marked drowsiness, dizziness and orthostatic effects.
How serious is the interaction between Dimenhydrinate and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and anticholinergic effects, especially in older adults. Reduce the dose or avoid dimenhydrinate if tolerability is poor.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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