Drug interactions
Dimenhydrinate + Lurasidone
Severity: Moderate
Dimenhydrinate and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate contains diphenhydramine and is sedating and anticholinergic. Combined with lurasidone it may increase drowsiness and cognitive impairment.
What this interaction means in plain words
Dimenhydrinate and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Monitor for sedation and confusion, especially in older adults. Use the lowest effective dose and avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Lurasidone?
MediHelp rates the interaction as moderate. Dimenhydrinate and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate contains diphenhydramine and is sedating and anticholinergic. Combined with lurasidone it may increase drowsiness and cognitive impairment.
How serious is the interaction between Dimenhydrinate and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and confusion, especially in older adults. Use the lowest effective dose and avoid driving if drowsy.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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