Drug interactions
Dimenhydrinate + Meperidine
Severity: Moderate
Dimenhydrinate and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating antihistamine that adds to opioid drowsiness and psychomotor impairment. Anticholinergic effects may also add, with confusion in older adults.
What this interaction means in plain words
Dimenhydrinate and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Counsel on drowsiness and avoid driving; reduce doses if oversedation occurs. Monitor older patients for confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Meperidine?
MediHelp rates the interaction as moderate. Dimenhydrinate and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating antihistamine that adds to opioid drowsiness and psychomotor impairment. Anticholinergic effects may also add, with confusion in older adults.
How serious is the interaction between Dimenhydrinate and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving; reduce doses if oversedation occurs. Monitor older patients for confusion.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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