Drug interactions
Dimenhydrinate + Midazolam
Severity: Moderate
Dimenhydrinate and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate is a sedating antihistamine, and combining it with midazolam increases drowsiness and impairment. Elderly patients are at higher risk of confusion and falls.
What this interaction means in plain words
Dimenhydrinate and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-antihistamine/anticholinergic action and benzodiazepine GABA-A potentiation.
What to do
Use a lower midazolam dose and titrate carefully. Monitor sedation and advise against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Midazolam?
MediHelp rates the interaction as moderate. Dimenhydrinate and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate is a sedating antihistamine, and combining it with midazolam increases drowsiness and impairment. Elderly patients are at higher risk of confusion and falls.
How serious is the interaction between Dimenhydrinate and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower midazolam dose and titrate carefully. Monitor sedation and advise against driving or operating machinery.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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