Drug interactions
Dimenhydrinate + Perphenazine
Severity: Moderate
Dimenhydrinate and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can produce more drowsiness, slowed reaction time and impaired psychomotor performance than either drug alone. Dimenhydrinate also has anticholinergic activity that may add to that of perphenazine.
What this interaction means in plain words
Dimenhydrinate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from sedating antihistamine and phenothiazine antipsychotic activity, with additive anticholinergic effects.
What to do
Warn the patient about sedation and avoid driving or operating machinery until the response is known. Reduce the dose or choose a non-sedating antiemetic if excessive drowsiness or anticholinergic effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dimenhydrinate and Perphenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dimenhydrinate with Perphenazine?
MediHelp rates the interaction as moderate. Dimenhydrinate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can produce more drowsiness, slowed reaction time and impaired psychomotor performance than either drug alone. Dimenhydrinate also has anticholinergic activity that may add to that of perphenazine.
How serious is the interaction between Dimenhydrinate and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about sedation and avoid driving or operating machinery until the response is known. Reduce the dose or choose a non-sedating antiemetic if excessive drowsiness or anticholinergic effects occur.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
