Drug interactions
Dimenhydrinate + Temazepam
Severity: Moderate
Dimenhydrinate and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam and dimenhydrinate together increase drowsiness, psychomotor impairment and the risk of falls, especially in older adults and into the next day.
What this interaction means in plain words
Dimenhydrinate and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dimenhydrinate belongs to Respiratory; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 antagonism.
What to do
Avoid regular combined use in older patients and use the lowest effective doses. Counsel on driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Dimenhydrinate with Temazepam?
MediHelp rates the interaction as moderate. Dimenhydrinate and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam and dimenhydrinate together increase drowsiness, psychomotor impairment and the risk of falls, especially in older adults and into the next day.
How serious is the interaction between Dimenhydrinate and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular combined use in older patients and use the lowest effective doses. Counsel on driving and alcohol avoidance.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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