Drug interactions
Diphenhydramine + Stiripentol
Severity: Moderate
Diphenhydramine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence, and diphenhydramine as a sedating antihistamine may add to drowsiness and dizziness. Stiripentol also inhibits several CYP enzymes, which could raise diphenhydramine exposure.
What this interaction means in plain words
Diphenhydramine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenhydramine belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible CYP inhibition by stiripentol raising diphenhydramine levels.
What to do
Counsel patients about additive drowsiness and avoid driving until the effect is known. Use the lowest diphenhydramine dose and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenhydramine
Other interactions of Stiripentol
Frequently asked questions
Can I take Diphenhydramine with Stiripentol?
MediHelp rates the interaction as moderate. Diphenhydramine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence, and diphenhydramine as a sedating antihistamine may add to drowsiness and dizziness. Stiripentol also inhibits several CYP enzymes, which could raise diphenhydramine exposure.
How serious is the interaction between Diphenhydramine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving until the effect is known. Use the lowest diphenhydramine dose and monitor for oversedation.
What other medicines interact with Diphenhydramine?
MediHelp also lists interactions of Diphenhydramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Diphenhydramine page.
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