Drug interactions
Diphenoxylate + Lurasidone
Severity: Moderate
Diphenoxylate and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid, and at high doses it can cause CNS depression. Combined with lurasidone, sedation and drowsiness may be increased.
What this interaction means in plain words
Diphenoxylate and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate belongs to Gastrointestinal Tract; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Monitor for increased sedation and impaired alertness, and keep diphenoxylate at the labeled dose. Advise patients to avoid driving until they know how the combination affects them.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Diphenoxylate with Lurasidone?
MediHelp rates the interaction as moderate. Diphenoxylate and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid, and at high doses it can cause CNS depression. Combined with lurasidone, sedation and drowsiness may be increased.
How serious is the interaction between Diphenoxylate and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and impaired alertness, and keep diphenoxylate at the labeled dose. Advise patients to avoid driving until they know how the combination affects them.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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