Drug interactions
Diphenoxylate + Nabilone
Severity: Moderate
Diphenoxylate and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid that can cause drowsiness and, in overdose, CNS and respiratory depression. Combined with nabilone, sedation and psychomotor impairment may be greater.
What this interaction means in plain words
Diphenoxylate and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate belongs to Gastrointestinal Tract; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid and cannabinoid effects.
What to do
Use the lowest effective doses and monitor for excessive drowsiness. Warn patients against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Diphenoxylate with Nabilone?
MediHelp rates the interaction as moderate. Diphenoxylate and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid that can cause drowsiness and, in overdose, CNS and respiratory depression. Combined with nabilone, sedation and psychomotor impairment may be greater.
How serious is the interaction between Diphenoxylate and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive drowsiness. Warn patients against driving and alcohol use.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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