Drug interactions
Diphenoxylate + Perphenazine
Severity: Moderate
Diphenoxylate and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid antidiarrheal that can cause CNS depression, particularly in overdose. Together with perphenazine, additive sedation is possible, and anticholinergic effects on the gut may be additive.
What this interaction means in plain words
Diphenoxylate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate belongs to Gastrointestinal Tract; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with additive antimuscarinic effects since diphenoxylate products contain atropine.
What to do
Use the recommended doses only and monitor for sedation, constipation and urinary retention. Counsel on avoiding alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Diphenoxylate with Perphenazine?
MediHelp rates the interaction as moderate. Diphenoxylate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid antidiarrheal that can cause CNS depression, particularly in overdose. Together with perphenazine, additive sedation is possible, and anticholinergic effects on the gut may be additive.
How serious is the interaction between Diphenoxylate and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the recommended doses only and monitor for sedation, constipation and urinary retention. Counsel on avoiding alcohol and other sedatives.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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