Drug interactions
Diphenoxylate-atropine + Fluphenazine
Severity: Moderate
Diphenoxylate-atropine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can cause sedation and has some anticholinergic activity, and diphenoxylate adds opioid-related central nervous system depression. The combination may increase drowsiness and anticholinergic adverse effects.
What this interaction means in plain words
Diphenoxylate-atropine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant and anticholinergic effects.
What to do
Monitor for oversedation and anticholinergic effects and counsel patients about driving. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Fluphenazine?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine can cause sedation and has some anticholinergic activity, and diphenoxylate adds opioid-related central nervous system depression. The combination may increase drowsiness and anticholinergic adverse effects.
How serious is the interaction between Diphenoxylate-atropine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects and counsel patients about driving. Use the lowest effective doses.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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