Drug interactions
Diphenoxylate-atropine + Glucagon
Severity: Moderate
Diphenoxylate-atropine and Glucagon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergics such as atropine can add to glucagon's inhibitory effect on gastrointestinal motility. Glucagon labeling notes an increased risk of GI adverse effects when used with anticholinergic drugs, mainly in diagnostic imaging. Clinically this is generally manageable.
What this interaction means in plain words
Diphenoxylate-atropine and Glucagon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Glucagon belongs to Endocrine.
Why it happens
Additive inhibition of gastrointestinal smooth muscle motility.
What to do
Avoid anticholinergic agents when glucagon is used as a GI diagnostic aid. For hypoglycemia rescue, give glucagon as needed and monitor for reduced bowel motility.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
- Glucagon + Hyoscyamine Moderate
Frequently asked questions
Can I take Diphenoxylate-atropine with Glucagon?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Glucagon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anticholinergics such as atropine can add to glucagon's inhibitory effect on gastrointestinal motility. Glucagon labeling notes an increased risk of GI adverse effects when used with anticholinergic drugs, mainly in diagnostic imaging. Clinically this is generally manageable.
How serious is the interaction between Diphenoxylate-atropine and Glucagon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid anticholinergic agents when glucagon is used as a GI diagnostic aid. For hypoglycemia rescue, give glucagon as needed and monitor for reduced bowel motility.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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