Drug interactions
Glucagon + Glycopyrrolate
Severity: Moderate
Glucagon and Glycopyrrolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon relaxes gastrointestinal smooth muscle, and glycopyrrolate also reduces gut motility. Taken together they can intensify slowing of the gut, causing constipation, bloating or, in susceptible patients, ileus. Clinical significance is usually modest when glucagon is given as a single diagnostic or rescue dose.
What this interaction means in plain words
Glucagon and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glucagon belongs to Endocrine; Glycopyrrolate belongs to Respiratory.
Why it happens
Additive inhibition of gastrointestinal motility through glucagon smooth muscle relaxation and antimuscarinic blockade.
What to do
Monitor for abdominal distension, constipation and reduced bowel sounds when both are used. For diagnostic imaging, expect additive effect and avoid repeated glucagon dosing without need.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrronium Moderate
- Glucagon + Hyoscyamine Moderate
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glucagon with Glycopyrrolate?
MediHelp rates the interaction as moderate. Glucagon and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucagon relaxes gastrointestinal smooth muscle, and glycopyrrolate also reduces gut motility. Taken together they can intensify slowing of the gut, causing constipation, bloating or, in susceptible patients, ileus. Clinical significance is usually modest when glucagon is given as a single diagnostic or rescue dose.
How serious is the interaction between Glucagon and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal distension, constipation and reduced bowel sounds when both are used. For diagnostic imaging, expect additive effect and avoid repeated glucagon dosing without need.
What other medicines interact with Glucagon?
MediHelp also lists interactions of Glucagon with, for example, Atropine, Benztropine, Dicyclomine. The full list is on the Glucagon page.
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