Drug interactions
Diphenoxylate-atropine + Iloperidone
Severity: Moderate
Diphenoxylate-atropine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has some antimuscarinic and sedating properties, and diphenoxylate is an opioid that causes CNS depression. Together with atropine they can increase sedation, constipation, urinary retention and dizziness.
What this interaction means in plain words
Diphenoxylate-atropine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from the opioid and antipsychotic, plus additive antimuscarinic effects.
What to do
Monitor for excessive sedation, orthostatic hypotension and anticholinergic effects, and counsel patients about driving. Use the lowest effective diphenoxylate-atropine dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Diphenoxylate-atropine with Iloperidone?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has some antimuscarinic and sedating properties, and diphenoxylate is an opioid that causes CNS depression. Together with atropine they can increase sedation, constipation, urinary retention and dizziness.
How serious is the interaction between Diphenoxylate-atropine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, orthostatic hypotension and anticholinergic effects, and counsel patients about driving. Use the lowest effective diphenoxylate-atropine dose for the shortest time.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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