Drug interactions
Diphenoxylate-atropine + Nabilone
Severity: Moderate
Diphenoxylate-atropine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone is a cannabinoid that causes drowsiness, dizziness and impaired cognition, and diphenoxylate may add to these effects. Combined use can reduce alertness and psychomotor performance.
What this interaction means in plain words
Diphenoxylate-atropine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and mental status and counsel patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Nabilone
Frequently asked questions
Can I take Diphenoxylate-atropine with Nabilone?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone is a cannabinoid that causes drowsiness, dizziness and impaired cognition, and diphenoxylate may add to these effects. Combined use can reduce alertness and psychomotor performance.
How serious is the interaction between Diphenoxylate-atropine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and mental status and counsel patients to avoid driving until the response is known.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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