Drug interactions
Diphenoxylate-atropine + Solifenacin
Severity: Moderate
Diphenoxylate-atropine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both products have antimuscarinic activity, so combining them increases anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients are at particular risk of confusion and ileus.
What this interaction means in plain words
Diphenoxylate-atropine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for urinary retention, constipation or ileus, and anticholinergic CNS effects, and avoid prolonged combined use. Consider stopping the antidiarrheal if abdominal distension or retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Solifenacin
Frequently asked questions
Can I take Diphenoxylate-atropine with Solifenacin?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both products have antimuscarinic activity, so combining them increases anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients are at particular risk of confusion and ileus.
How serious is the interaction between Diphenoxylate-atropine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation or ileus, and anticholinergic CNS effects, and avoid prolonged combined use. Consider stopping the antidiarrheal if abdominal distension or retention develops.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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