Drug interactions
Diphenoxylate-atropine + Ziconotide
Severity: Moderate
Diphenoxylate-atropine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide is an intrathecal analgesic that commonly causes sedation, dizziness, confusion and impaired cognition. Adding the opioid diphenoxylate may worsen these CNS effects.
What this interaction means in plain words
Diphenoxylate-atropine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression; ziconotide blocks N-type calcium channels while diphenoxylate acts at opioid receptors.
What to do
Monitor for sedation and cognitive changes, and reduce the dose of one agent or stop it if mental status worsens. Prefer to avoid unnecessary CNS depressants during ziconotide titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Diphenoxylate-atropine with Ziconotide?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide is an intrathecal analgesic that commonly causes sedation, dizziness, confusion and impaired cognition. Adding the opioid diphenoxylate may worsen these CNS effects.
How serious is the interaction between Diphenoxylate-atropine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and reduce the dose of one agent or stop it if mental status worsens. Prefer to avoid unnecessary CNS depressants during ziconotide titration.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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