Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine + Hydroxychloroquine
Severity: Minor
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Hydroxychloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
All components are non-live, and hydroxychloroquine does not meaningfully reduce vaccine immunogenicity. No clinically important interaction is expected.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild immunomodulation may theoretically blunt antibody responses; mechanism is not well established.
What to do
Vaccinate on schedule; continue hydroxychloroquine unchanged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine with Hydroxychloroquine?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. All components are non-live, and hydroxychloroquine does not meaningfully reduce vaccine immunogenicity. No clinically important interaction is expected.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis / poliovirus inactivated vaccine and Hydroxychloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule; continue hydroxychloroquine unchanged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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