Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Everolimus
Severity: Minor
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Everolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus may reduce the immune response to the Tdap/DTaP vaccine, giving weaker or shorter protection. The vaccine is non-live, so it is not unsafe.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Everolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
mTOR inhibition reduces lymphocyte proliferation and antibody production.
What to do
Give inactivated vaccines as indicated, preferably before starting everolimus. Consider antibody testing or boosters if protection is uncertain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Everolimus?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Everolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Everolimus may reduce the immune response to the Tdap/DTaP vaccine, giving weaker or shorter protection. The vaccine is non-live, so it is not unsafe.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Everolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give inactivated vaccines as indicated, preferably before starting everolimus. Consider antibody testing or boosters if protection is uncertain.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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