Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Hydroxychloroquine
Severity: Minor
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Hydroxychloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a non-live combination vaccine, and hydroxychloroquine is not expected to meaningfully impair the response. No clinically important interaction is expected.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild immunomodulation by hydroxychloroquine may theoretically blunt antibody production; not well established.
What to do
Vaccinate as scheduled without altering hydroxychloroquine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Hydroxychloroquine?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This is a non-live combination vaccine, and hydroxychloroquine is not expected to meaningfully impair the response. No clinically important interaction is expected.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Hydroxychloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as scheduled without altering hydroxychloroquine.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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