Drug interactions
Diphtheria and tetanus toxoids / acellular pertussis vaccine + Temsirolimus
Severity: Moderate
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from temsirolimus may lessen the immune response to this inactivated combination vaccine. The vaccine itself cannot cause infection, but protection may be incomplete.
What this interaction means in plain words
Diphtheria and tetanus toxoids / acellular pertussis vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses lymphocyte function and so reduces vaccine immunogenicity.
What to do
Vaccinate before starting temsirolimus where possible. If given during therapy, consider revaccination once treatment has finished.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids / acellular pertussis vaccine with Temsirolimus?
MediHelp rates the interaction as moderate. Diphtheria and tetanus toxoids / acellular pertussis vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from temsirolimus may lessen the immune response to this inactivated combination vaccine. The vaccine itself cannot cause infection, but protection may be incomplete.
How serious is the interaction between Diphtheria and tetanus toxoids / acellular pertussis vaccine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting temsirolimus where possible. If given during therapy, consider revaccination once treatment has finished.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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