Drug interactions
Diphtheria and tetanus toxoids + Infliximab
Severity: Minor
Diphtheria and tetanus toxoids and Infliximab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These toxoid vaccines are non-live and safe in patients taking infliximab, though the antibody response may be somewhat reduced. Vaccination should not be withheld.
What this interaction means in plain words
Diphtheria and tetanus toxoids and Infliximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF-alpha inhibition may modestly blunt humoral responses to vaccine antigens.
What to do
Give indicated toxoid boosters as scheduled; no change in infliximab therapy is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Diphtheria and tetanus toxoids with Infliximab?
MediHelp rates the interaction as minor. Diphtheria and tetanus toxoids and Infliximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. These toxoid vaccines are non-live and safe in patients taking infliximab, though the antibody response may be somewhat reduced. Vaccination should not be withheld.
How serious is the interaction between Diphtheria and tetanus toxoids and Infliximab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give indicated toxoid boosters as scheduled; no change in infliximab therapy is needed.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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