Drug interactions
Dipipanone + Mirtazapine
Severity: Moderate
Dipipanone and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is a potent opioid analgesic, and combining it with the sedating antidepressant mirtazapine can increase drowsiness, cognitive impairment and respiratory depression. Risk is greatest at the start of therapy or after dose increases.
What this interaction means in plain words
Dipipanone and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and histamine H1 antagonism.
What to do
Start with reduced doses and titrate cautiously, and monitor sedation and respiratory rate. Advise patients against driving and avoid adding other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Dipipanone with Mirtazapine?
MediHelp rates the interaction as moderate. Dipipanone and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipipanone is a potent opioid analgesic, and combining it with the sedating antidepressant mirtazapine can increase drowsiness, cognitive impairment and respiratory depression. Risk is greatest at the start of therapy or after dose increases.
How serious is the interaction between Dipipanone and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses and titrate cautiously, and monitor sedation and respiratory rate. Advise patients against driving and avoid adding other CNS depressants.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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