Drug interactions
Dipipanone + Tramadol
Severity: Major
Dipipanone and Tramadol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tramadol with dipipanone, a potent opioid, adds respiratory and CNS depression. Tramadol may also provoke withdrawal or reduce analgesia in patients dependent on strong opioids and lowers seizure threshold.
What this interaction means in plain words
Dipipanone and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive opioid effects and mu-receptor competition, with tramadol's added monoamine reuptake inhibition.
What to do
Avoid combining; use a single opioid. If unavoidable, monitor for sedation, respiratory depression and withdrawal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Dipipanone with Tramadol?
MediHelp rates the interaction as major. Dipipanone and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tramadol with dipipanone, a potent opioid, adds respiratory and CNS depression. Tramadol may also provoke withdrawal or reduce analgesia in patients dependent on strong opioids and lowers seizure threshold.
How serious is the interaction between Dipipanone and Tramadol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use a single opioid. If unavoidable, monitor for sedation, respiratory depression and withdrawal.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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