Drug interactions
Dipyridamole + Edoxaban
Severity: Moderate
Dipyridamole and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole has antiplatelet effects and may inhibit P-glycoprotein, so it can add to edoxaban bleeding risk through both pharmacodynamic and pharmacokinetic routes.
What this interaction means in plain words
Dipyridamole and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dipyridamole belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Why it happens
Additive antiplatelet and anticoagulant effects, plus possible P-gp inhibition raising edoxaban levels.
What to do
Monitor for bleeding and hemoglobin; reassess the need for dipyridamole if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dipyridamole and Edoxaban, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Dipyridamole with Edoxaban?
MediHelp rates the interaction as moderate. Dipyridamole and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole has antiplatelet effects and may inhibit P-glycoprotein, so it can add to edoxaban bleeding risk through both pharmacodynamic and pharmacokinetic routes.
How serious is the interaction between Dipyridamole and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin; reassess the need for dipyridamole if bleeding occurs.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
