Drug interactions
Dipyridamole + Metoprolol
Severity: Minor
Dipyridamole and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole raises adenosine levels, which can slow sinus and AV nodal activity, and metoprolol has similar effects. Together they may cause bradycardia or conduction delay, particularly in susceptible patients.
What this interaction means in plain words
Dipyridamole and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dipyridamole belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Dipyridamole blocks adenosine reuptake, enhancing adenosine-mediated nodal slowing that adds to beta-1 blockade.
What to do
Monitor heart rate and ECG in patients with conduction abnormalities, and during dipyridamole stress testing watch for bradycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Dipyridamole with Metoprolol?
MediHelp rates the interaction as minor. Dipyridamole and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dipyridamole raises adenosine levels, which can slow sinus and AV nodal activity, and metoprolol has similar effects. Together they may cause bradycardia or conduction delay, particularly in susceptible patients.
How serious is the interaction between Dipyridamole and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with conduction abnormalities, and during dipyridamole stress testing watch for bradycardia.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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