Drug interactions
Disulfiram + Sevoflurane
Severity: Minor
Disulfiram and Sevoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram inhibits CYP2E1, which contributes to sevoflurane metabolism. This may reduce production of fluoride and other metabolites, with little expected effect on anesthetic action.
What this interaction means in plain words
Disulfiram and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP2E1-mediated sevoflurane biotransformation by disulfiram.
What to do
No specific action is usually needed beyond routine anesthetic monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Disulfiram with Sevoflurane?
MediHelp rates the interaction as minor. Disulfiram and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram inhibits CYP2E1, which contributes to sevoflurane metabolism. This may reduce production of fluoride and other metabolites, with little expected effect on anesthetic action.
How serious is the interaction between Disulfiram and Sevoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is usually needed beyond routine anesthetic monitoring.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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