Drug interactions
Divalproex + Repotrectinib
Severity: Moderate
Divalproex and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 inducer with some effect on UGT enzymes, which could modestly lower valproate exposure. Because CYP3A4 is not a major route of valproate clearance, the effect is uncertain.
What this interaction means in plain words
Divalproex and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Repotrectinib induces metabolic enzymes, possibly increasing valproate clearance, though the contribution is not well established.
What to do
Monitor valproate serum concentrations and seizure or mood control after starting or stopping repotrectinib. Adjust the valproate dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Divalproex with Repotrectinib?
MediHelp rates the interaction as moderate. Divalproex and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib is a CYP3A4 inducer with some effect on UGT enzymes, which could modestly lower valproate exposure. Because CYP3A4 is not a major route of valproate clearance, the effect is uncertain.
How serious is the interaction between Divalproex and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor valproate serum concentrations and seizure or mood control after starting or stopping repotrectinib. Adjust the valproate dose according to levels and clinical response.
What other medicines interact with Repotrectinib?
MediHelp also lists interactions of Repotrectinib with, for example, Apalutamide, Amiodarone, Amobarbital. The full list is on the Repotrectinib page.
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