Drug interactions
Dobutamine + Entacapone
Severity: Moderate
Dobutamine and Entacapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine is a catecholamine partly cleared by COMT, and entacapone inhibits this enzyme. Exposure to dobutamine may rise, producing stronger tachycardia, arrhythmia or blood pressure changes.
What this interaction means in plain words
Dobutamine and Entacapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Entacapone belongs to Central Nervous System.
Why it happens
Entacapone inhibits catechol-O-methyltransferase, reducing methylation and clearance of dobutamine.
What to do
Monitor heart rate, rhythm and blood pressure during dobutamine infusion and use the lowest effective infusion rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dobutamine and Entacapone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dobutamine
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Dobutamine with Entacapone?
MediHelp rates the interaction as moderate. Dobutamine and Entacapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine is a catecholamine partly cleared by COMT, and entacapone inhibits this enzyme. Exposure to dobutamine may rise, producing stronger tachycardia, arrhythmia or blood pressure changes.
How serious is the interaction between Dobutamine and Entacapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure during dobutamine infusion and use the lowest effective infusion rate.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
