Drug interactions
Dobutamine + Hydrochlorothiazide-lisinopril
Severity: Moderate
Dobutamine and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine can lower serum potassium through beta-2 mediated cellular uptake, and this adds to the potassium loss from hydrochlorothiazide. Hypokalemia during inotropic therapy increases the risk of arrhythmias.
What this interaction means in plain words
Dobutamine and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Beta-adrenergic stimulation shifts potassium into cells while the thiazide increases renal potassium excretion, producing additive hypokalemia.
What to do
Monitor serum potassium and ECG during dobutamine infusion and replace potassium as needed. Consider holding the thiazide in acute settings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Dobutamine and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine can lower serum potassium through beta-2 mediated cellular uptake, and this adds to the potassium loss from hydrochlorothiazide. Hypokalemia during inotropic therapy increases the risk of arrhythmias.
How serious is the interaction between Dobutamine and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dobutamine infusion and replace potassium as needed. Consider holding the thiazide in acute settings.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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