Drug interactions
Dobutamine + Indacaterol-glycopyrronium
Severity: Moderate
Dobutamine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine is a sympathomimetic inotrope, and indacaterol is a long-acting beta2-agonist. Combining them can potentiate adrenergic effects, causing tachycardia, arrhythmias, tremor, hypokalemia and blood pressure changes. This matters most in patients with cardiovascular disease.
What this interaction means in plain words
Dobutamine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive beta-adrenergic stimulation.
What to do
Monitor heart rate, rhythm, blood pressure and serum potassium during dobutamine infusion in patients using indacaterol. Titrate dobutamine to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Dobutamine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine is a sympathomimetic inotrope, and indacaterol is a long-acting beta2-agonist. Combining them can potentiate adrenergic effects, causing tachycardia, arrhythmias, tremor, hypokalemia and blood pressure changes. This matters most in patients with cardiovascular disease.
How serious is the interaction between Dobutamine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm, blood pressure and serum potassium during dobutamine infusion in patients using indacaterol. Titrate dobutamine to the lowest effective dose.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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