Drug interactions
Dobutamine + Labetalol
Severity: Moderate
Dobutamine and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol can oppose the inotropic and chronotropic effects of dobutamine, reducing its benefit. Unopposed alpha-adrenergic effects of dobutamine may also alter blood pressure unpredictably.
What this interaction means in plain words
Dobutamine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: beta-receptor blockade by labetalol opposes dobutamine's beta-1 agonist effects.
What to do
Monitor hemodynamics closely and expect to need higher dobutamine doses. Avoid the combination if possible, or withhold labetalol when inotropic support is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Labetalol?
MediHelp rates the interaction as moderate. Dobutamine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol can oppose the inotropic and chronotropic effects of dobutamine, reducing its benefit. Unopposed alpha-adrenergic effects of dobutamine may also alter blood pressure unpredictably.
How serious is the interaction between Dobutamine and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemodynamics closely and expect to need higher dobutamine doses. Avoid the combination if possible, or withhold labetalol when inotropic support is required.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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