Drug interactions
Dobutamine + Promethazine
Severity: Minor
Dobutamine and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine is a short-acting intravenous inotrope and promethazine is a sedating phenothiazine with alpha-blocking and mild proarrhythmic properties. A clear interaction is not well documented, although phenothiazines may cause hypotension or arrhythmia in a patient receiving catecholamine support.
What this interaction means in plain words
Dobutamine and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dobutamine belongs to Cardiovascular; Promethazine belongs to Respiratory.
Why it happens
No established mechanism; possible opposing hemodynamic effects from alpha-adrenergic blockade and additive arrhythmic potential.
What to do
Monitor blood pressure and ECG during concurrent intravenous use and titrate dobutamine to hemodynamic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Promethazine?
MediHelp rates the interaction as minor. Dobutamine and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dobutamine is a short-acting intravenous inotrope and promethazine is a sedating phenothiazine with alpha-blocking and mild proarrhythmic properties. A clear interaction is not well documented, although phenothiazines may cause hypotension or arrhythmia in a patient receiving catecholamine support.
How serious is the interaction between Dobutamine and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG during concurrent intravenous use and titrate dobutamine to hemodynamic response.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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