Drug interactions
Docetaxel + Dronedarone
Severity: Moderate
Docetaxel and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein and is a moderate CYP3A4 inhibitor, and docetaxel is cleared mainly by CYP3A4. Exposure to docetaxel may rise, increasing myelosuppression, neutropenia, fluid retention and neurotoxicity.
What this interaction means in plain words
Docetaxel and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism and P-glycoprotein efflux by dronedarone reduces docetaxel clearance.
What to do
Monitor blood counts and signs of docetaxel toxicity closely, and consider dose reduction if adverse effects emerge. Consider an alternative antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Dronedarone?
MediHelp rates the interaction as moderate. Docetaxel and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits P-glycoprotein and is a moderate CYP3A4 inhibitor, and docetaxel is cleared mainly by CYP3A4. Exposure to docetaxel may rise, increasing myelosuppression, neutropenia, fluid retention and neurotoxicity.
How serious is the interaction between Docetaxel and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of docetaxel toxicity closely, and consider dose reduction if adverse effects emerge. Consider an alternative antiarrhythmic if feasible.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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