Drug interactions
Docetaxel + Eliglustat
Severity: Moderate
Docetaxel and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and could increase docetaxel exposure, a P-gp substrate. The clinical impact is not well characterized.
What this interaction means in plain words
Docetaxel and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Eliglustat belongs to Miscellaneous.
Why it happens
Eliglustat inhibits P-glycoprotein efflux, potentially raising docetaxel levels.
What to do
Monitor for docetaxel toxicity such as neutropenia and reduce the dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Docetaxel with Eliglustat?
MediHelp rates the interaction as moderate. Docetaxel and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein and could increase docetaxel exposure, a P-gp substrate. The clinical impact is not well characterized.
How serious is the interaction between Docetaxel and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for docetaxel toxicity such as neutropenia and reduce the dose if toxicity occurs.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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