Drug interactions
Docetaxel + Etravirine
Severity: Moderate
Docetaxel and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may reduce docetaxel exposure, potentially lowering its effectiveness. It also has some inhibitory activity, so the net effect is uncertain.
What this interaction means in plain words
Docetaxel and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4, increasing docetaxel metabolism.
What to do
Monitor tumor response and docetaxel toxicity. Consider an alternative antiretroviral without enzyme-inducing effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Docetaxel with Etravirine?
MediHelp rates the interaction as moderate. Docetaxel and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may reduce docetaxel exposure, potentially lowering its effectiveness. It also has some inhibitory activity, so the net effect is uncertain.
How serious is the interaction between Docetaxel and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and docetaxel toxicity. Consider an alternative antiretroviral without enzyme-inducing effects.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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