Drug interactions
Docetaxel + Fosaprepitant
Severity: Minor
Docetaxel and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor and may modestly raise docetaxel exposure. Clinical studies have generally found no meaningful change, and the combination is widely used as antiemetic prophylaxis.
What this interaction means in plain words
Docetaxel and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Docetaxel belongs to Oncology; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant weakly to moderately inhibits CYP3A4, slightly reducing docetaxel metabolism.
What to do
No dose adjustment is generally required. Monitor for docetaxel toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Docetaxel
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Docetaxel with Fosaprepitant?
MediHelp rates the interaction as minor. Docetaxel and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, formed from fosaprepitant, is a moderate CYP3A4 inhibitor and may modestly raise docetaxel exposure. Clinical studies have generally found no meaningful change, and the combination is widely used as antiemetic prophylaxis.
How serious is the interaction between Docetaxel and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required. Monitor for docetaxel toxicity as usual.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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