Drug interactions
Docetaxel + Iloperidone
Severity: Minor
Docetaxel and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak time-dependent CYP3A inhibitor and may modestly raise docetaxel levels. The effect is likely small but docetaxel has a narrow therapeutic index.
What this interaction means in plain words
Docetaxel and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Docetaxel belongs to Oncology; Iloperidone belongs to Central Nervous System.
Why it happens
Weak, time-dependent inhibition of CYP3A4 reduces docetaxel metabolism.
What to do
No routine dose change is needed. Watch for enhanced docetaxel toxicity such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Docetaxel
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Docetaxel with Iloperidone?
MediHelp rates the interaction as minor. Docetaxel and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak time-dependent CYP3A inhibitor and may modestly raise docetaxel levels. The effect is likely small but docetaxel has a narrow therapeutic index.
How serious is the interaction between Docetaxel and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for enhanced docetaxel toxicity such as neutropenia.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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