Drug interactions
Docetaxel + Ivacaftor
Severity: Moderate
Docetaxel and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its metabolite weakly inhibit P-glycoprotein and CYP3A, which could modestly increase docetaxel exposure. Clinical significance is uncertain but docetaxel has a narrow therapeutic index.
What this interaction means in plain words
Docetaxel and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor inhibits P-glycoprotein and weakly CYP3A, decreasing docetaxel efflux and metabolism.
What to do
Monitor blood counts and docetaxel-related toxicity, and consider dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Docetaxel with Ivacaftor?
MediHelp rates the interaction as moderate. Docetaxel and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor and its metabolite weakly inhibit P-glycoprotein and CYP3A, which could modestly increase docetaxel exposure. Clinical significance is uncertain but docetaxel has a narrow therapeutic index.
How serious is the interaction between Docetaxel and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and docetaxel-related toxicity, and consider dose reduction if toxicity develops.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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