Drug interactions
Docetaxel + Lomitapide
Severity: Moderate
Docetaxel and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and could raise docetaxel exposure, while lomitapide is a sensitive CYP3A4 substrate whose exposure depends on CYP3A4 activity. Docetaxel is not a significant CYP3A4 inhibitor, so the main concern is docetaxel toxicity and additive hepatotoxicity.
What this interaction means in plain words
Docetaxel and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Lomitapide belongs to Cardiovascular.
Why it happens
Lomitapide inhibits P-glycoprotein, reducing docetaxel efflux.
What to do
Monitor blood counts, liver enzymes and docetaxel toxicity, and consider docetaxel dose reduction if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Docetaxel with Lomitapide?
MediHelp rates the interaction as moderate. Docetaxel and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and could raise docetaxel exposure, while lomitapide is a sensitive CYP3A4 substrate whose exposure depends on CYP3A4 activity. Docetaxel is not a significant CYP3A4 inhibitor, so the main concern is docetaxel toxicity and additive hepatotoxicity.
How serious is the interaction between Docetaxel and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver enzymes and docetaxel toxicity, and consider docetaxel dose reduction if toxicity occurs.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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