Drug interactions
Docetaxel + Midazolam
Severity: Minor
Docetaxel and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel is a CYP3A4 substrate and is not a clinically meaningful inhibitor, so large changes in midazolam exposure are unlikely. Any effect would be small.
What this interaction means in plain words
Docetaxel and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Docetaxel belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
Possible minor competition for CYP3A4; no established inhibition.
What to do
Titrate midazolam to effect and monitor sedation in debilitated oncology patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Midazolam?
MediHelp rates the interaction as minor. Docetaxel and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Docetaxel is a CYP3A4 substrate and is not a clinically meaningful inhibitor, so large changes in midazolam exposure are unlikely. Any effect would be small.
How serious is the interaction between Docetaxel and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to effect and monitor sedation in debilitated oncology patients.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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