Drug interactions
Docetaxel + Oxaliplatin
Severity: Moderate
Docetaxel and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia, and together the risk of severe neutropenia and infection increases. Both can also cause peripheral neuropathy that may be additive.
What this interaction means in plain words
Docetaxel and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive myelosuppression and neurotoxicity from two cytotoxic agents.
What to do
Monitor blood counts and neuropathy, adjusting doses or using growth factors as needed. When given sequentially, infuse the taxane before oxaliplatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Oxaliplatin?
MediHelp rates the interaction as moderate. Docetaxel and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neutropenia, and together the risk of severe neutropenia and infection increases. Both can also cause peripheral neuropathy that may be additive.
How serious is the interaction between Docetaxel and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, adjusting doses or using growth factors as needed. When given sequentially, infuse the taxane before oxaliplatin.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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