Drug interactions
Docetaxel + Sirolimus
Severity: Moderate
Docetaxel and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is a P-glycoprotein and CYP3A4 substrate with weak inhibitory activity, so a clinically meaningful rise in docetaxel levels is uncertain. Additive myelosuppression and immunosuppression may be of greater practical concern.
What this interaction means in plain words
Docetaxel and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Possible competition for P-glycoprotein and CYP3A4 handling, plus additive immunosuppression; the pharmacokinetic effect is not well established.
What to do
Monitor blood counts and infection signs during co-therapy, and check sirolimus trough levels if clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Docetaxel with Sirolimus?
MediHelp rates the interaction as moderate. Docetaxel and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus is a P-glycoprotein and CYP3A4 substrate with weak inhibitory activity, so a clinically meaningful rise in docetaxel levels is uncertain. Additive myelosuppression and immunosuppression may be of greater practical concern.
How serious is the interaction between Docetaxel and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs during co-therapy, and check sirolimus trough levels if clinically indicated.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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