Drug interactions
Docetaxel + Tacrolimus
Severity: Moderate
Docetaxel and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A4 and P-glycoprotein substrates and may compete for elimination, potentially raising either drug's levels. Added immunosuppression and myelosuppression increase infection risk.
What this interaction means in plain words
Docetaxel and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Competition for CYP3A4 metabolism and P-glycoprotein efflux, plus additive immunosuppressive effects.
What to do
Monitor tacrolimus trough levels, renal function, blood counts and docetaxel toxicity; adjust doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Docetaxel with Tacrolimus?
MediHelp rates the interaction as moderate. Docetaxel and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CYP3A4 and P-glycoprotein substrates and may compete for elimination, potentially raising either drug's levels. Added immunosuppression and myelosuppression increase infection risk.
How serious is the interaction between Docetaxel and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels, renal function, blood counts and docetaxel toxicity; adjust doses accordingly.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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