Drug interactions
Docetaxel + Tipranavir
Severity: Major
Docetaxel and Tipranavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, co-administered with ritonavir, inhibits CYP3A4 and may substantially raise docetaxel levels. This can intensify neutropenia, mucositis and other toxicities.
What this interaction means in plain words
Docetaxel and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Docetaxel belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated docetaxel metabolism (with ritonavir) reduces clearance.
What to do
Avoid if possible; otherwise reduce docetaxel dose and monitor blood counts and toxicity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Docetaxel
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Docetaxel with Tipranavir?
MediHelp rates the interaction as major. Docetaxel and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, co-administered with ritonavir, inhibits CYP3A4 and may substantially raise docetaxel levels. This can intensify neutropenia, mucositis and other toxicities.
How serious is the interaction between Docetaxel and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce docetaxel dose and monitor blood counts and toxicity closely.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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