Drug interactions
Dolasetron + Donepezil
Severity: Moderate
Dolasetron and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil has been associated with QT prolongation and torsades de pointes, and dolasetron also prolongs QT. Combined use raises arrhythmia risk, and donepezil's vagotonic bradycardia adds to it.
What this interaction means in plain words
Dolasetron and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus bradycardia from cholinesterase inhibition.
What to do
Obtain an ECG in patients with bradycardia or other QT risk factors and correct electrolytes. Prefer an alternative antiemetic when risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Dolasetron with Donepezil?
MediHelp rates the interaction as moderate. Dolasetron and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil has been associated with QT prolongation and torsades de pointes, and dolasetron also prolongs QT. Combined use raises arrhythmia risk, and donepezil's vagotonic bradycardia adds to it.
How serious is the interaction between Dolasetron and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with bradycardia or other QT risk factors and correct electrolytes. Prefer an alternative antiemetic when risk is high.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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