Drug interactions
Dolasetron + Erythromycin stearate
Severity: Major
Dolasetron and Erythromycin stearate: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron's active metabolite prolongs the PR, QRS and QT intervals, and erythromycin is a recognized QT-prolonging macrolide. Combined use raises the risk of torsades de pointes, especially with electrolyte abnormalities or structural heart disease.
What this interaction means in plain words
Dolasetron and Erythromycin stearate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Avoid the combination where possible and choose a non-QT-prolonging antiemetic or antibiotic. If unavoidable, correct potassium and magnesium and monitor ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Erythromycin stearate?
MediHelp rates the interaction as major. Dolasetron and Erythromycin stearate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dolasetron's active metabolite prolongs the PR, QRS and QT intervals, and erythromycin is a recognized QT-prolonging macrolide. Combined use raises the risk of torsades de pointes, especially with electrolyte abnormalities or structural heart disease.
How serious is the interaction between Dolasetron and Erythromycin stearate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-QT-prolonging antiemetic or antibiotic. If unavoidable, correct potassium and magnesium and monitor ECG.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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