Drug interactions
Dolasetron + Escitalopram
Severity: Moderate
Dolasetron and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and escitalopram's effect is dose-related. Both also affect serotonergic transmission, so serotonin syndrome is a theoretical but reported concern with 5-HT3 antagonists plus SSRIs.
What this interaction means in plain words
Dolasetron and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Escitalopram belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible additive serotonergic effects.
What to do
Monitor ECG in patients with cardiac risk factors and keep escitalopram at the lowest effective dose. Watch for agitation, tremor, hyperthermia and clonus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dolasetron and Escitalopram, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Dolasetron with Escitalopram?
MediHelp rates the interaction as moderate. Dolasetron and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs prolong the QT interval, and escitalopram's effect is dose-related. Both also affect serotonergic transmission, so serotonin syndrome is a theoretical but reported concern with 5-HT3 antagonists plus SSRIs.
How serious is the interaction between Dolasetron and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and keep escitalopram at the lowest effective dose. Watch for agitation, tremor, hyperthermia and clonus.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
